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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta name="description" content="News of Bioinformatics and Interdisciplinary Technologies (BITs)">
<meta name="author" content="Bioinformatics and Interdisciplinary Technologies (BITs)">
<link rel="shortcut icon" href="/static/image/favicon.ico">
<title>Bioinformatics and Interdisciplinary Technologies (BITs) — Yang Lab</title>
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<body>
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<!--<h1><img src="/static/image/favicon.png" alt="logo">Computational Biology and Biotechnologies (Yang Lab) <br> <text>on genomics, transcriptomics and genome editing<text></h1>-->
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<a class="uk-navbar-brand uk-hidden-small" href="#">Yang Lab</a>
<ul class="uk-navbar-nav uk-hidden-small">
<li><a href="/index"><i class="uk-icon-home"></i> Home</a></li>
<!-- <li><a href="/research"><i class="uk-icon-laptop"></i> Research</a></li> -->
<li><a href="/news"><i class="uk-icon-newspaper-o"></i> News</a></li>
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<!--<li><a href="/SM"><i class="uk-icon-cubes"></i> Supplementary Materials</a></li>-->
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<div class="uk-navbar-brand uk-navbar-center uk-visible-small">Yang Lab</div>
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<article class="uk-article">
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<div class="uk-width-1-1">
<h2 class="uk-article-title">News</h2>
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<h2>2026</h2>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">February:</span>
Yao-Qi, Fang and Li have contributed an article in Cell Research. Congratulations!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41422-026-01233-9"></a>
</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">January:</span>
Li has been selected as one of the 2025 Most Cited Chinese Researchers (released by Elsevier). Congratulations to Li!
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<img class="uk-container-center" src="/static/image/news/2026/Elsevier_most_cited_LiYang_2025.jpg" alt="2026/Elsevier_most_cited_LiYang_2025.jpg">
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<h2>2025</h2>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">November:</span>
Li has been selected as Highly Cited Researcher 2025 (released by Clarivate). Congratulations to Li!
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<img class="uk-container-center" src="/static/image/news/2025/Clarivate_Highly_Cited_LiYang.jpg" alt="2025/Clarivate_Highly_Cited_LiYang.jpg">
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<span class="uk-text-bold uk-text-danger">November:</span>
Guo-Hua has passed the dissertation defense! Congratulations!
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<img class="uk-container-center" src="/static/image/news/2025/Yuan_Graduate_1.jpg" alt="2025/Yuan_Graduate_1.jpg">
<img class="uk-container-center" src="/static/image/news/2025/Yuan_Graduate_2.jpg" alt="2025/Yuan_Graduate_2.jpg">
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<span class="uk-text-bold uk-text-danger">October:</span>
Si-Nan, Yu-Yao, Mo-Han, Zhi-Can, Xu-Kai and Li have published an article in Nucleic Acids Research. Well done!
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<a class="uk-icon-external-link" href="https://doi.org/10.1093/nar/gkaf1039"></a>
</p>
<!--<div id="166_news" class="uk-hidden">-->
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<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
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<span class="uk-text-bold uk-text-danger">September:</span>
Mei, Guo-Hua, Jia, Yi-Lin and Li have contributed an article in Nature communications. Congratulations!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41467-025-63686-7"></a>
</p>
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<span class="uk-text-bold uk-text-danger">September:</span>
Pei-Hong, Hua, Xu-Kai, Fang and Li have contributed an article in Genomics, Proteomics & Bioinformatics. Congratulations!
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<a class="uk-icon-external-link" href="https://doi.org/10.1093/gpbjnl/qzaf089"></a>
</p>
<!--<div id="164_news" class="uk-hidden">-->
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<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">July:</span>
Yu-Yao and Li have contributed an article in Nature. Congratulations!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41586-025-09412-1"></a>
</p>
<!--<div id="163_news" class="uk-hidden">-->
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<span class="uk-text-bold uk-text-danger">June:</span>
Zhi-Can and Bao-Qing have graduated from SINH! Congratulations!
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<div class="uk-text-center">
<img class="uk-container-center" src="/static/image/news/2025/Zhican_Baoqing.jpg" alt="2025/Zhican_Baoqing.jpg">
<img class="uk-container-center" src="/static/image/news/2025/YangGroup_2025.jpg" alt="2025/YangGroup_2025.jpg">
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<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">May:</span>
Bao-Qing, Yu-Yao and Li have contributed an article in Cell. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://www.cell.com/cell/fulltext/S0092-8674(25)00514-8"></a>
</p>
<!--<div id="161_news" class="uk-hidden">-->
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<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Guo-Hua, Yao-Qi and Li have contributed an article in Briefings in Bioinformatics. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://academic.oup.com/bib/article/26/2/bbaf152/8110879"></a>
</p>
<!--<div id="160_news" class="uk-hidden">-->
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Fang and Li have contributed an article in RNA. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://rnajournal.cshlp.org/content/early/2025/03/27/rna.080341.124"></a>
</p>
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<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Si-Nan, Jia and Li have contributed an article in Nature Biotechnology. Well done!
<!---->
<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41587-025-02624-w"></a>
</p>
<!--<div id="158_news" class="uk-hidden">-->
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<span class="uk-text-bold uk-text-danger">March:</span>
Guo-Hua, Jia and Li have contributed an article in Nature Biotechnology. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41587-025-02591-2"></a>
</p>
<!--<div id="157_news" class="uk-hidden">-->
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<span class="uk-text-bold uk-text-danger">March:</span>
Bao-Qing and Li have contributed an article in Nature Biotechnology. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41587-025-02608-w"></a>
</p>
<!--<div id="156_news" class="uk-hidden">-->
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">March:</span>
Li has been selected as one of the 2024 Most Cited Chinese Researchers (released by Elsevier). Congratulations to Li!
<!---->
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<span class="uk-text-bold uk-text-danger">February:</span>
Si-Nan, Jia, Yi-Lin and Li have contributed an article in Molecular Cell. Congratulations!
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<a class="uk-icon-external-link" href="https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00046-2"></a>
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<h2>2024</h2>
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<span class="uk-text-bold uk-text-danger">December:</span>
Bao-Qing and Li have contributed an article in Science Bulletin. Congratulations!
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<a class="uk-icon-external-link" href="https://www.sciencedirect.com/science/article/pii/S2095927324004080?via%3Dihub"></a>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">December:</span>
Li has been selected as the 2024 Highly Cited Researcher (released by Clarivate). Congratulations to Li!
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<span class="uk-text-bold uk-text-danger">October:</span>
Zhi-Can, Bao-Qing, Fang, Xu-Kai & Li have published an article in Genome Biology. Awesome job!
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<a class="uk-icon-external-link" href="https://doi.org/10.1186/s13059-024-03397-2"></a>
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<p>This study developed DEMINING, a computational framework using DeepDDR to directly distinguish RNA editing from DNA mutations in RNA-seq, revealing novel mutations and RNA editing events linked to gene expression and neoantigen production in acute myeloid leukemia patients.</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">October:</span>
Li has contributed an article in Molecular Cell. Congratulations!
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<a class="uk-icon-external-link" href="https://doi.org/10.1016/j.molcel.2024.08.020"></a>
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<span class="uk-text-bold uk-text-danger">August:</span>
Xu-Kai and Li have contributed an article in The Innovation Life. Congratulations!
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<a class="uk-icon-external-link" href="https://www.the-innovation.org/article/doi/10.59717/j.xinn-life.2024.100083"></a>
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<span class="uk-text-bold uk-text-danger">July:</span>
Pei-Hong and Li have contributed an article in Life Science Alliance. Well done!
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<span class="uk-text-bold uk-text-danger">July:</span>
Bao-Qing and Li have contributed an article in Nature Methods. Congratulations!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41592-024-02333-3"></a>
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<span class="uk-text-bold uk-text-danger">June:</span>
Guo-Hua and Li have contributed an article in Molecular Cell. Well done!
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<a class="uk-icon-external-link" href="https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00434-9"></a>
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<p>This study identified that a subset of adenosine (A)-rich circRNAs are restricted in H9 nuclei but exported to cytosols upon differentiation. Such a subcellular relocation of circRNAs is modulated by the poly(A)-binding protein PABPC1. Decreased nuclear PABPC1 upon neuronal differentiation enables the export of (A)-rich circRNAs, including circRTN4(2,3), which is required for neurite outgrowth.</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">May:</span>
Pei-Hong has passed the dissertation defense! Congratulations!
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<img class="uk-container-center" src="/static/image/news/2024/GroupPhoto_Pei-Hong%26Li.jpg" alt="2024/GroupPhoto_Pei-Hong&Li.jpg">
<img class="uk-container-center" src="/static/image/news/2024/GroupPhoto_Guo-Wei%26PIs_1.jpg" alt="2024/GroupPhoto_Guo-Wei&PIs_1.jpg">
<img class="uk-container-center" src="/static/image/news/2024/GroupPhoto_YangLab_Pei-Hong.jpg" alt="2024/GroupPhoto_YangLab_Pei-Hong.jpg">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Fang, Jia and Li have contributed an article in Nature Biotechnology. Congratulations!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41587-024-02204-4"></a>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">March:</span>
Li has been selected as one of the 2023 Most Cited Chinese Researchers (released by Elsevier). Congratulations to Li!
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<div class="uk-text-center">
<img class="uk-container-center" src="/static/image/news/2024/2023Elsevier_Highly_Cited_Chinese_Researchers_LiYang.jpg" alt="2024/2023Elsevier_Highly_Cited_Chinese_Researchers_LiYang.jpg">
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<!--<p class="uk-article-lead" style="margin:0;">-->
<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">March:</span>
Fang, Hua and Li have contributed an article in Cell. Congratulations!
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<a class="uk-icon-external-link" href="https://doi.org/10.1016/j.cell.2024.02.005"></a>
</p>
<!--<div id="141_news" class="uk-hidden">-->
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">February:</span>
Xu-Kai, Mei, and Li have contributed a chapter in Methods in Molecular Biology. Well done!
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<a class="uk-icon-external-link" href="https://link.springer.com/protocol/10.1007/978-1-0716-3678-7_11"></a>
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<h2>2023</h2>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">December:</span>
Li has been selected as the 2023 Highly Cited Researcher (released by Clarivate). Congratulations to Li!
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<img class="uk-container-center" src="/static/image/news/2023/2023_Clarivate_Highly_Cited_Researchers_li.jpg" alt="2023/2023_Clarivate_Highly_Cited_Researchers_li.jpg">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">November:</span>
Si-Nan, Xu-Kai and Li have contributed an article in Molecular Cell. Well done!
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<a class="uk-icon-external-link" href="https://www.sciencedirect.com/science/article/pii/S1097276523009024"></a>
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<p>This study unveiled Integrator subunits 6 (IntS6) over-expression blocks Integrator function by titrating Integrator phosphatase module (PP2A-AC) to modulate premature termination of only a subset of Integrator-regulated genes in Drosophila and PP2A-B subunits (tws/wdb) not normally associated with Integrator can also regulate the efficiency of select premature transcription termination events.</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">November:</span>
Zhi-Can, Jia, Yi-Lin and Li have contributed an article in Cell Stem Cell. Congratulations!
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<a class="uk-icon-external-link" href="https://doi.org/10.1016/j.stem.2023.10.007"></a>
</p>
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<p>This study effectively induced elevated fetal hemoglobin levels in hematopoietic stem/progenitor cells from both healthy and b-thalassemia patients using the Transformer Base Editor (tBE), with no observed off-target mutations. The persistent therapeutic effects of tBE on repopulating hematopoietic stem cells underscore its potential as a safe and effective strategy for treating b-hemoglobinopathies.</p>
</div>
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<span class="uk-text-bold uk-text-danger">November:</span>
Li has contributed an article in Science Bulletin. Well done!
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<a class="uk-icon-external-link" href="https://www.sciencedirect.com/science/article/abs/pii/S2095927323007259"></a>
</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">October:</span>
Xu-Kai, Si-Nan and Li have contributed an article in Trend in Genetics. Congratulations!
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<a class="uk-icon-external-link" href="https://www.cell.com/trends/genetics/fulltext/S0168-9525(23)00223-8"></a>
</p>
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<div id="135_news">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">October:</span>
Bao-Qing and Li have contributed an article in Nature Protocols. Well done!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41596-023-00877-w"></a>
</p>
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<p>This paper describes the experimental protocol and computational pipeline for the design and application of the transformer base editor (tBE) in mammalian cells and in mice.</p>
</div>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">September:</span>
Bao-Qing, Jia and Li have contributed an article in MedComm. Congratulations!
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<a class="uk-icon-external-link" href="https://doi.org/10.1002/mco2.356"></a>
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<p>This study used prime editor (PE) to precisely edit ACE2 at structurally selected sites, and demonstrated that residue changes at Q24/D30/K31 and/or K353 of ACE2 could completely ablate the binding of tested viruses while maintaining its physiological role in host angiotensin II conversion. </p>
</div>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">July:</span>
Guo-Hua and Li have contributed an article in Nature Methods. Well done!
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<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41592-023-01944-6"></a>
</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">May:</span>
Pei-Hong and Li have contributed an article in Molecular Cancer. Well done!
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<a class="uk-icon-external-link" href="https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01785-z"></a>
</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Li has been selected as the 2022 Highly Cited Researcher (released by Clarivate). Congratulations to Li!
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<div class="uk-text-center">
<img class="uk-container-center" src="/static/image/news/2023/2022_Clarivate_Highly_Cited_Chinese_Researchers_li.jpg" alt="2023/2022_Clarivate_Highly_Cited_Chinese_Researchers_li.jpg">
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<!--<p class="uk-article-lead" style="margin:0;">-->
<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">April:</span>
Li has been selected as one of the 2022 Most Cited Chinese Researchers (released by Elsevier). Congratulations to Li!
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<div class="uk-text-center">
<img class="uk-container-center" src="/static/image/news/2023/2022_Highly_Cited_Chinese_Researchers_v1.jpg" alt="2023/2022_Highly_Cited_Chinese_Researchers_v1.jpg">
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">March:</span>
Pei-Hong and Li have contributed an article in Nature. Congratulations!
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<!---->
<a class="uk-icon-external-link" href="https://www.nature.com/articles/s41586-023-05767-5"></a>
</p>
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<div id="128_news">
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<p>This work uses high-resolution live-cell microscopy to screen 200 candidate nucleolar proteins, reveal the superfine structure of the nucleoli, provide insight into the functional sub-nucleolar organization and identify a physiologically essential step in rRNA maturation that requires the static protein URB1 in the phase-separated nucleolus.</p>
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<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">February:</span>
We celebrate the opening of new Fudan IBS workspace.
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<div class="uk-text-center">
<img class="uk-container-center" src="/static/image/news/2023/team_IBS_opening.jpg" alt="2023/team_IBS_opening.jpg">
</div>
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</div>
<div class="uk-panel uk-margin-top-remove uk-margin-bottom-remove">
<!--<p class="uk-article-lead" style="margin:0;">-->
<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">February:</span>
Ying and Li have contributed an article in Science Advances. Congratulations!
<!---->
<a class="uk-icon-external-link" href="https://www.science.org/doi/10.1126/sciadv.abo6405"></a>
</p>
<!--<div id="126_news" class="uk-hidden">-->
<div id="126_news">
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<!--<p class="uk-article-lead" style="margin:0;">-->
<p class="uk-article-lead uk-margin-top-remove uk-margin-bottom-remove">
<span class="uk-text-bold uk-text-danger">January:</span>
Bao-Qing and Li have contributed an article in Genome Biology. Well done!
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<!---->
<a class="uk-icon-external-link" href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-02848-6"></a>
</p>
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<div id="125_news">
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<!--word-->
<p>This study optimized CRISPR-Cas13 (dCas13) system to enable robust spatial-temporal tracking of endogenous mRNAs and uncover features of transcription and mRNP
motion.</p>
</div>
</div>
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